Clifton is an unincorporated community in Mason County, West Virginia, United States. Clifton is located on the east bank of the Ohio River along West Virginia Route 62, 1.5 miles (2.4 km) south of Mason; Middleport, Ohio lies across the river. Clifton had a post office, which closed on May 24, 1997. As of the 2020 census, Clifton had a population of 277.