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Desert Center is a census-designated place in the Colorado Desert in Riverside County, California. It is in southern California, between the cities of Indio and Blythe at the junction of Interstate 10 and State Route 177, about halfway between Phoenix and Los Angeles. The ZIP Code is 92239, and the community is in telephone area codes 442 and 760. The elevation is 656 feet (200 m). The population was 256 at the 2020 census.