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Gaffney is a city in and the seat of Cherokee County, South Carolina, United States, in the Upstate region of South Carolina. Gaffney is known as the "Peach Capital of South Carolina". The population was 12,764 at the 2020 census. The city had an estimated population of 12,609 in 2019. It is the principal city of the Gaffney, South Carolina, Micropolitan Statistical Area, which includes all of Cherokee County and which is further included in the greater Greenville-Spartanburg-Anderson, South Carolina Combined Statistical Area. Gaffney was the home of Limestone University, which operated from 1845 until 2025.