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Grand Saline is a city in Van Zandt County, Texas, United States, located in East Texas. The population was 3,107 as of 2020, making Grand Saline the third-largest city in Van Zandt County. The city is located roughly 75 miles (120 km) east of Dallas and 35 miles (56 km) northwest of Tyler, the two nearest metropolitan areas, and is part of the greater Tyler/Longview area.