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High Point is a city in the Piedmont Triad region of the U.S. state of North Carolina. Most of the city is in Guilford County, with parts extending into Randolph, Davidson, and Forsyth counties. As of the 2020 census the city had a total population of 114,059. High Point is the ninth-most populous in North Carolina, the third-largest municipality in the Piedmont Triad, and the 259th-most populous city in the U.S.