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Holly Springs is a city in and the county seat of Marshall County, Mississippi, United States, near the border with Tennessee to the north. As of the 2020 census, the population was 6,968, down from 7,699 in 2010. Along with the Mississippi Delta, in the 19th century, the area was developed for cotton plantations. After the Civil War, many freedmen continued to work in agriculture as sharecroppers and tenant farmers.