Homestead is a small unincorporated community in northern Blaine County, Oklahoma, United States. As of the 2020 census, Homestead had a population of 41. The town was platted along the Choctaw Northern Railroad before statehood. The Homestead Post Office opened January 26, 1893. Homestead had a population of 150 residents in 1905, according to the Oklahoma Territorial Census. The town lost rail service around 1926.