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Hosford is an unincorporated community and census-designated place in Liberty County, Florida, United States. Its population was 650 as of the 2020 Census. It is located at the junction of State Road 20 and State Road 65. Hosford has a post office with ZIP Code 32334. It has one school, Hosford Elementary School and Jr. High School, and a public library, Jimmy Weaver Memorial Public Library. Hosford is the site of a Georgia-Pacific mill.