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Irene is a city in Clay, Turner, and Yankton counties in South Dakota, United States. The population was 422 at the 2020 census. The portion of Irene that is located in Turner County is a part of the Sioux Falls, South Dakota metropolitan area, the portion located in Yankton County is part of the Yankton Micropolitan Statistical Area, and the portion located in Clay County is part of both the Vermillion Micropolitan Statistical Area and the Sioux City-Vermillion Combined Statistical Area. Irene is also host to the Irene Rodeo, held every summer.