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Isabela is a town and municipality of Puerto Rico located in the north-western region of the island, north of San Sebastián; west of Quebradillas; and east of Aguadilla and Moca. It is named in honor of Queen Isabella I of Castile. Isabela is spread over 13 barrios and Isabela Pueblo, which is the downtown area and administrative center. It is a principal part of the Aguadilla-Isabela-San Sebastián Metropolitan Statistical Area.