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Long Creek is a city in Grant County, Oregon, United States. The population was 173 at the 2020 census. The city is named after John Long, a prominent miner who came to Grant County in 1862 during the Canyon City rush of that same year. Located in a high valley of the Blue Mountains, ranching has been the principal enterprise for the area. Log harvesting was slowly curtailed in the nearby Malheur National Forest until the local mill was closed in 1998.