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Lopezville is a census-designated place (CDP) in Hidalgo County, Texas, United States. The population was 2,367 at the 2020 United States Census. It is part of the McAllen–Edinburg–Mission Metropolitan Statistical Area. The town developed during the early 1960s as a trailer park. It is named for Francisco Solano López, a former president of Paraguay, a descendant of whom founded his namesake trailer park.