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Madison is a city in and the county seat of Jefferson County, Indiana, United States, along the Ohio River. As of the 2020 census, Madison had a population of 12,357. Over 55,000 people live within 15 miles (24 km) of downtown Madison. Madison is the largest city along the Ohio River between Louisville and Cincinnati. In 2006, the majority of Madison's downtown area was designated a National Historic Landmark—133 blocks of the downtown area is known as the Madison Historic Landmark District.