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Moose Creek is a census-designated place (CDP) in Fairbanks North Star Borough in the U.S. state of Alaska. As of the 2020 census, Moose Creek had a population of 534. It is part of the Fairbanks, Alaska Metropolitan Statistical Area. Moose Creek is located south of Fairbanks, Alaska along the Richardson Highway. Moose Creek is bordered by Eielson Air Force Base to the south, the Tanana River to the west, and the Chena River Flood Control Project to the north.