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Natrona is an unincorporated community in Harrison Township, Allegheny County, Pennsylvania. It is located in western Pennsylvania within the Pittsburgh Metropolitan Statistical Area, approximately 24 miles (39 km) northeast of Downtown Pittsburgh. Natrona is situated along the Allegheny River at Lock and Dam Four, Pools Three and Four between Brackenridge, Natrona Heights, Karns, Allegheny Township, and Lower Burrell.