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Pickens, formerly called Pickens Courthouse, is a city in and the county seat of Pickens County, South Carolina, United States. As of the 2020 census, Pickens had a population of 3,388. Pickens changed its classification from a town to a city in 1998, but it was not reported to the Census Bureau until 2001. It was named after Andrew Pickens, an American revolutionary soldier and US Congressman for South Carolina.