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Piedmont is a city in northwestern Wayne County in Southeast Missouri, United States. Its population was 1,897 at the 2020 census. Part of the Ozark Foothills Region, it is at the convergence of State Highways 34 and 49. Piedmont, transliterated as "foot of the mountain," is named for its position at the foot of Clark Mountain, a 1424-foot summit approximately two miles north of the town.