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Punta Santiago is a barrio and fishing community located in the municipality of Humacao, Puerto Rico. Its population in 2020 was 3,716. Located in the estuary of Humacao, Punta Santiago is famous for its fishing heritage, its iconic pier and Cayo Santiago, popularly known as Monkey Island after its Rhesus macaque population. The barrio is also the home of the Humacao Nature Reserve and the Punta Santiago Beach and Vacation Area. Punta Santiago is one of the most vulnerable barrios to flooding and complete destruction whenever hurricanes enter Puerto Rico through the area of Humacao.