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Roanoke is an independent city in Virginia, United States. It lies in Southwest Virginia along the Roanoke River, within the Blue Ridge range of the greater Appalachian Mountains. Roanoke is about 50 miles (80 km) north of the Virginia–North Carolina border and 250 miles (400 km) southwest of Washington, D.C., along Interstate 81. At the 2020 census, Roanoke's population was 100,011, making it the most populous city in Virginia west of the state capital, Richmond. It is the primary population center of the Roanoke metropolitan area, which had a population of 315,251 in 2020.