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Santee is a town in Orangeburg County along the Santee River Valley in central South Carolina, United States. It has become a resort town of note located centrally north-south along the Atlantic Seaboard of South Carolina. The region has been rural, with a primarily agricultural economy typical of Orangeburg County, but is now known primarily for its several golf courses in proximity to Lake Marion, Santee State Park and other Lake Marion attractions. Interstate 95 connects its attractions easily with tourists traveling by automobile. I-95 crosses a narrow arm of the lake into the town lands, along a causeway. Lake Marion is a man-made hydroelectric reservoir, which at 110,000 acres is one of the fifty largest lakes in the country.