Serena's
Daily Encourager

Serena is an unincorporated community and census-designated place in LaSalle County, Illinois, United States. As of the 2020 census, Serena had a population of 129. Serena has a post office with ZIP code 60549. Serena was the residence of Peg McDonnell Breslin, the first woman elected to the Illinois Appellate Court outside Cook County.