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Sycamore is a town in Allendale County, South Carolina, United States. As of the 2020 census, Sycamore had a population of 147. On April 5, 2022, the town was hit by an EF3 tornado, although it had weakened to EF1 strength by the time it moved through town and only minor damage occurred. One person was injured by this tornado south of Allendale, South Carolina.