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Wilkes-Barre is a city in Pennsylvania, which functions as both the administrative hub and the primary population center of Luzerne County. Located along the Susquehanna River in Northeastern Pennsylvania, it had a population of 44,661 in the 2024 census. It is part of the Wyoming Valley metropolitan area, which includes five cities and more than 40 boroughs forming a contiguous urban corridor with an estimated 574,000 residents.