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Wise is a town in Wise County, Virginia. The population was 2,970 at the 2020 census. It is the county seat of Wise County. It was originally incorporated as the town of Gladeville in 1874. The town's name was changed to Wise in 1924, after Henry A. Wise, the last Virginia governor before the American Civil War and the first governor to hail from the Eastern Shore of Virginia.